Sam Phiri is a clinician, clinical epidemiologist, and principal investigator/Executive Director for Lighthouse Trust in Lilongwe, Malawi. With over 15 years’ experience in HIV program design and implementation, he provides strategic leadership to the Lighthouse, a WHO Centre of Excellence in integrated HIV prevention, treatment, and care. Lighthouse innovations and initiatives have informed both national and international HIV policies. Several large program and research grants have supported Lighthouse to become a leader in model interventions in care, prevention of mother-to-child transmission (PMTCT), and antiretroviral treatment (ART). Professor Phiri’s interests focus on integration of HIV prevention, treatment, and care: TB/HIV integration; linkages among family planning/PMTCT/ART; and management of HIV-related cancers, mental health, and non-communicable diseases. He has played a leadership role in the design, implementation, and results dissemination of implementation science. He is Professor in the Department of Medicine at University of North Carolina School of Medicine, Chapel Hill, USA; Department of Global Health at the University of Washington, Seattle, USA; and Senior Lecturer in the Department of Public Health at the University of Malawi, College of Medicine School of Public Health and Family Medicine, Lilongwe, providing teaching, mentorship, supervision for students conducting their projects in Malawi.